Standard Coupling Procedures; DIC/HOBt; PyBOP; HBTU ...
Standard DIC/HOBt Coupling. Remove the N-terminal protecting group by standard deprotection protocols.Suspend the resin in dichloromethane (DCM, 10 mL per gram resin) Dissolve 5 equivalents (based on resin substitution) in DMF (approximately 1 mL per gram) of amino acid derivative. Dissolve 5.5 equivalents (based on resin substitution) of HOBt ...
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